This Drug Should Not Be Taken If. • you are allergic to either clindamycin or lincomycin.

• you are allergic to either clindamycin or lincomycin.

• it is prescribed for a mild or trivial infection such as a cold, sore throat
or " flu-like" illness.

• you have a history of Crohn's disease or ulcerative colitis.

Inform Your Physician Before Taking This Drug If

• you have a history of allergy to any drug.

• you have a history of drug-induced colitis.

• you are allergic by nature: hay fever, asthma, hives, eczema.

• you have a history of previous yeast infections.

• you have myasthenia gravis.

• you have impaired liver or kidney function.

• you plan to have surgery under general anesthesia in the near future.

Possible Side-Effects (natural, expected and unavoidable drug actions) Superinfections (see Glossary).

Possible Adverse Effects(unusual, unexpected and infrequent reactions) Ifany of the following develop, consult your physician promptly for guidance.

Mild Adverse Effects

Allergic Reactions: Skin rashes (3% to 5%), hives.

Nausea, vomiting, mild diarrhea (3% to 30%), stomach pain.

Multiple joint pains (rare). Serious Adverse Effects

Allergic Reactions: Severe skin reactions: erythema multiforme (Stevens-Johnson syndrome).

Toxic liver reaction with jaundice.

Severe colitis with persistent diarrhea (0.01% to 10%); stools may contain blood and/or mucus.

Rare reduction of white blood cell and platelet counts.

Possible Effects on Sexual Function: None reported.

Possible Delayed Adverse Effects: Severe colitis with diarrhea (pseudo-membranous colitis) may begin several weeks after discontinuing this drug.

Adverse Effects That May Mimic Natural Diseases or Disorders

Liver reactions may suggest viral hepatitis.

Multiple joint pains may suggest the onset of arthritis.

Natural Diseases or Disorders That May Be Activated by This Drug

Crohn's disease, ulcerative colitis, myasthenia gravis.

Possible Effects on Laboratory Tests

Complete blood cell counts: decreased white cells and platelets; increased

eosinophils (allergic reaction). Liver function tests: uncommon, mild and transient increases in liver

enzymes (ALT/GPT, AST/GOT, alkaline phosphatase).

CAUTION

1. Troublesome and persistent diarrhea can develop in sensitive in­-
dividuals. If diarrhea persists longer than 24 hours, discontinue this
drug and consult your physician for guidance.

2. If surgery under general anesthesia is planned while taking this drug,
the choice of anesthetic must be considered carefully to prevent
excessive muscle relaxation and associated impairment of breathing.