Advisability of Use if Breast-Feeding

Presence of this drug in breast milk: Yes, in small amounts. Monitor nursing infant closely and discontinue drug or nursing if adverse effects develop.

Habit-Forming Potential: None.

Effects of Overdosage: Excessive drop in blood pressure lightheadedness, dizziness, fainting.

Possible Effects of Long-Term Use: Gradual increase in blood potassium level.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion)

Before starting drug: Complete blood cell counts; urine analysis with measurement of protein content, blood potassium level. During use of drug: Blood cell counts every 2 weeks during the first 3 months of treatment, then periodically for duration of use. Urine protein measurements every month during the first 9 months of treatment, then periodically for duration of use. Periodic measurements of blood potassium.

While Taking This Drug, Observe the Following

Foods: Consult physician regarding salt intake.

Nutritional Support: Do not take potassium supplements unless directed by

your physician.

Beverages: No restrictions. May be taken with milk.

Alcohol: Use caution until combined effect has been determined. Alcohol

may enhance the blood-pressure-lowering effect of this drug.

Tobacco Smoking: No interactions expected.

Other Drugs

Captopril taken concurrently with

• potassium preparations (K-Lyte, Slow-K, etc.) may cause increased blood levels of potassium with risk of serious heart rhythm disturbances.

• potassium-sparing diuretics: amiloride (Moduretic), spironolactone (Aldactazide), triamterene (Dyazide) may cause increased blood levels of potassium with risk of serious heart rhythm disturbances.

The following drugs may decrease the effects of captopril

• indomethacin (Indocin).

• salicylates (aspirin, etc.).

Driving, Hazardous Activities: Usually no restrictions. Be aware of possible drops in blood

Aviation Note: The use of this drug may be a disqualification for piloting. Consult a designated Aviation Medical Examiner.

Exposure to Sun: Caution advised. This drug can cause photosensitivity.

Exposure to Heat: Caution advised. Avoid excessive perspiring with resultant loss of body water and drop in blood pressure.

Occurrence of Unrelated Illness: Report promptly any disorder that causes nausea, vomiting or diarrhea. Fluid and chemical imbalances must be corrected as soon as possible.

TEXT 4. Read the following text and choose the abstract about using metronidazole by a pregnant woman.